Associations between visceral fat and liver fat with insulin sensitivity and metabolic risk in obese adolescents.
Identifieur interne : 000616 ( Main/Exploration ); précédent : 000615; suivant : 000617Associations between visceral fat and liver fat with insulin sensitivity and metabolic risk in obese adolescents.
Auteurs : Ruth E. Brown [Canada] ; Jennifer L. Kuk [Canada] ; Ingrid Libman [États-Unis] ; Michelle Rivera-Vega [États-Unis] ; Sojung Lee [États-Unis]Source :
- Biochemistry and cell biology = Biochimie et biologie cellulaire [ 1208-6002 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Foie, Graisse intra-abdominale, Insuline, Obésité.
- Adolescent, Enfant, Essais contrôlés randomisés comme sujet, Facteurs de risque, Femelle, Humains, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Insulin.
- metabolism : Intra-Abdominal Fat, Liver, Obesity.
- Adolescent, Child, Female, Humans, Male, Randomized Controlled Trials as Topic, Risk Factors.
Abstract
We examined the joint and independent associations between VAT and LF with insulin sensitivity (IS) and lipids in seventy-one obese adolescents (BMI ≥ 95th, 14.9 ± 1.8 years). VAT was assessed by magnetic resonance imaging, and LF was quantified by proton magnetic resonance spectroscopy. IS was evaluated by a 3 -h hyperinsulinemic (80 mU·m(-2)·min(-1)) euglycemic clamp. Independent associations between VAT and LF on metabolic variables were assessed in mutually adjusted multivariate models. The joint association between VAT and LF on metabolic variables was assessed by categorizing participants into a low VAT + low LF group (n = 35), high VAT + low LF group (n = 26), or high VAT + high LF group (n = 10), based on a VAT median split (1.17 kg) and high (≥5%) and low (<5%) LF. Both VAT and LF were independently associated with fasting insulin, 2 h insulin, insulin AUC, IS, and triglycerides (P < 0.05). Adolescents with high VAT + high LF had higher 2 h glucose, glucose AUC, 2 h insulin, triglycerides, and lower insulin sensitivity compared to adolescents with high VAT only (P < 0.025 for all). In obese adolescents, VAT and LF were independently associated with insulin sensitivity and dyslipidemia, and the concomitant presence of VAT and LF is strongly associated with metabolic risk factors.
DOI: 10.1139/bcb-2014-0064
PubMed: 25643243
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000117
- to stream PubMed, to step Curation: 000117
- to stream PubMed, to step Checkpoint: 000117
- to stream Ncbi, to step Merge: 004756
- to stream Ncbi, to step Curation: 004756
- to stream Ncbi, to step Checkpoint: 004756
- to stream Main, to step Merge: 000616
- to stream Main, to step Curation: 000616
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Associations between visceral fat and liver fat with insulin sensitivity and metabolic risk in obese adolescents.</title><author><name sortKey="Brown, Ruth E" sort="Brown, Ruth E" uniqKey="Brown R" first="Ruth E" last="Brown">Ruth E. Brown</name><affiliation wicri:level="1"><nlm:affiliation>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3</wicri:regionArea><wicri:noRegion>ON M3J 1P3</wicri:noRegion></affiliation></author><author><name sortKey="Kuk, Jennifer L" sort="Kuk, Jennifer L" uniqKey="Kuk J" first="Jennifer L" last="Kuk">Jennifer L. Kuk</name><affiliation wicri:level="1"><nlm:affiliation>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3</wicri:regionArea><wicri:noRegion>ON M3J 1P3</wicri:noRegion></affiliation></author><author><name sortKey="Libman, Ingrid" sort="Libman, Ingrid" uniqKey="Libman I" first="Ingrid" last="Libman">Ingrid Libman</name><affiliation wicri:level="2"><nlm:affiliation>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Rivera Vega, Michelle" sort="Rivera Vega, Michelle" uniqKey="Rivera Vega M" first="Michelle" last="Rivera-Vega">Michelle Rivera-Vega</name><affiliation wicri:level="2"><nlm:affiliation>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lee, Sojung" sort="Lee, Sojung" uniqKey="Lee S" first="Sojung" last="Lee">Sojung Lee</name><affiliation wicri:level="2"><nlm:affiliation>c Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Ave., Faculty Pavilion (6102), Pittsburgh, PA 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>c Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Ave., Faculty Pavilion (6102), Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25643243</idno><idno type="pmid">25643243</idno><idno type="doi">10.1139/bcb-2014-0064</idno><idno type="wicri:Area/PubMed/Corpus">000117</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000117</idno><idno type="wicri:Area/PubMed/Curation">000117</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000117</idno><idno type="wicri:Area/PubMed/Checkpoint">000117</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000117</idno><idno type="wicri:Area/Ncbi/Merge">004756</idno><idno type="wicri:Area/Ncbi/Curation">004756</idno><idno type="wicri:Area/Ncbi/Checkpoint">004756</idno><idno type="wicri:Area/Main/Merge">000616</idno><idno type="wicri:Area/Main/Curation">000616</idno><idno type="wicri:Area/Main/Exploration">000616</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Associations between visceral fat and liver fat with insulin sensitivity and metabolic risk in obese adolescents.</title><author><name sortKey="Brown, Ruth E" sort="Brown, Ruth E" uniqKey="Brown R" first="Ruth E" last="Brown">Ruth E. Brown</name><affiliation wicri:level="1"><nlm:affiliation>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3</wicri:regionArea><wicri:noRegion>ON M3J 1P3</wicri:noRegion></affiliation></author><author><name sortKey="Kuk, Jennifer L" sort="Kuk, Jennifer L" uniqKey="Kuk J" first="Jennifer L" last="Kuk">Jennifer L. Kuk</name><affiliation wicri:level="1"><nlm:affiliation>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3</wicri:regionArea><wicri:noRegion>ON M3J 1P3</wicri:noRegion></affiliation></author><author><name sortKey="Libman, Ingrid" sort="Libman, Ingrid" uniqKey="Libman I" first="Ingrid" last="Libman">Ingrid Libman</name><affiliation wicri:level="2"><nlm:affiliation>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Rivera Vega, Michelle" sort="Rivera Vega, Michelle" uniqKey="Rivera Vega M" first="Michelle" last="Rivera-Vega">Michelle Rivera-Vega</name><affiliation wicri:level="2"><nlm:affiliation>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lee, Sojung" sort="Lee, Sojung" uniqKey="Lee S" first="Sojung" last="Lee">Sojung Lee</name><affiliation wicri:level="2"><nlm:affiliation>c Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Ave., Faculty Pavilion (6102), Pittsburgh, PA 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>c Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Ave., Faculty Pavilion (6102), Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Biochemistry and cell biology = Biochimie et biologie cellulaire</title><idno type="eISSN">1208-6002</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Humans</term><term>Insulin (metabolism)</term><term>Intra-Abdominal Fat (metabolism)</term><term>Liver (metabolism)</term><term>Male</term><term>Obesity (metabolism)</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de risque</term><term>Femelle</term><term>Foie (métabolisme)</term><term>Graisse intra-abdominale (métabolisme)</term><term>Humains</term><term>Insuline (métabolisme)</term><term>Mâle</term><term>Obésité (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intra-Abdominal Fat</term><term>Liver</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Foie</term><term>Graisse intra-abdominale</term><term>Insuline</term><term>Obésité</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the joint and independent associations between VAT and LF with insulin sensitivity (IS) and lipids in seventy-one obese adolescents (BMI ≥ 95th, 14.9 ± 1.8 years). VAT was assessed by magnetic resonance imaging, and LF was quantified by proton magnetic resonance spectroscopy. IS was evaluated by a 3 -h hyperinsulinemic (80 mU·m(-2)·min(-1)) euglycemic clamp. Independent associations between VAT and LF on metabolic variables were assessed in mutually adjusted multivariate models. The joint association between VAT and LF on metabolic variables was assessed by categorizing participants into a low VAT + low LF group (n = 35), high VAT + low LF group (n = 26), or high VAT + high LF group (n = 10), based on a VAT median split (1.17 kg) and high (≥5%) and low (<5%) LF. Both VAT and LF were independently associated with fasting insulin, 2 h insulin, insulin AUC, IS, and triglycerides (P < 0.05). Adolescents with high VAT + high LF had higher 2 h glucose, glucose AUC, 2 h insulin, triglycerides, and lower insulin sensitivity compared to adolescents with high VAT only (P < 0.025 for all). In obese adolescents, VAT and LF were independently associated with insulin sensitivity and dyslipidemia, and the concomitant presence of VAT and LF is strongly associated with metabolic risk factors.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Brown, Ruth E" sort="Brown, Ruth E" uniqKey="Brown R" first="Ruth E" last="Brown">Ruth E. Brown</name></noRegion><name sortKey="Kuk, Jennifer L" sort="Kuk, Jennifer L" uniqKey="Kuk J" first="Jennifer L" last="Kuk">Jennifer L. Kuk</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Libman, Ingrid" sort="Libman, Ingrid" uniqKey="Libman I" first="Ingrid" last="Libman">Ingrid Libman</name></region><name sortKey="Lee, Sojung" sort="Lee, Sojung" uniqKey="Lee S" first="Sojung" last="Lee">Sojung Lee</name><name sortKey="Rivera Vega, Michelle" sort="Rivera Vega, Michelle" uniqKey="Rivera Vega M" first="Michelle" last="Rivera-Vega">Michelle Rivera-Vega</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000616 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000616 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25643243
|texte= Associations between visceral fat and liver fat with insulin sensitivity and metabolic risk in obese adolescents.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25643243" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |